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Fritsch, J., P. Scheerer, S. Frielingsdorf, S. Kroschinsky, B. Friedrich, O. Lenz, and C. M. Spahn. 2011. The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre. Nature 479:249-252.  PubMed

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Bürstel, I., P. Hummel, E. Siebert, N. Wisitruangsakul, I. Zebger, B. Friedrich, and O. Lenz. 2011. Probing the origin of the metabolic precursor of the CO ligand in the catalytic center of [NiFe]-hydrogenase. J Biol Chem 286:44937-44944.  PubMed

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Lukey, M. J., M. M. Roessler, A. Parkin, R. M. Evans, R. A. Davies, O. Lenz, B. Friedrich,F. Sargent, and F. A. Armstrong. 2011. Oxygen-Tolerant [NiFe]-Hydrogenases: The Individual and Collective Importance of Supernumerary Cysteines at the Proximal Fe-S Cluster. J Am Chem Soc 133:16881-16892. PubMed

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Fritsch, J., S. Löscher, O. Sanganas, E. Siebert, I. Zebger, M. Stein, M. Ludwig, A. L. De Lacey, H. Dau, B. Friedrich, O. Lenz, and M. Haumann. 2011. [NiFe] and [FeS] cofactors in the membrane-bound hydrogenase of Ralstonia eutropha investigated by X-ray absorption spectroscopy: insights into O₂-tolerant H₂ cleavage. Biochemistry 50:5858-5869.  PubMed

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Bleijlevens, B., T. Buhrke, E. van der Linden, B. Friedrich, and S. P. Albracht. 2004. The auxiliary protein HypX provides oxygen tolerance to the soluble [NiFe]-hydrogenase of Ralstonia eutropha H16 by way of a cyanide ligand to nickel. J Biol Chem. 279:46686-91.  PubMed

Buhrke, T., O. Lenz, A. Porthun, and B. Friedrich. 2004. The H₂-sensing complex of Ralstonia eutropha: interaction between a regulatory [NiFe] hydrogenase and a histidine protein kinase. Mol Microbiol. 51:1677-89.  PubMed

Jones, A. K., O. Lenz, A. Strack, T. Buhrke, and B. Friedrich. 2004. NiFe hydrogenase active site biosynthesis: identification of Hyp protein complexes in Ralstonia eutropha. Biochemistry. 43:13467-77.  PubMed

Pötter, M., H. Müller, F. Reinecke, R. Wieczorek, F. Fricke, B. Bowien, B. Friedrich, and A. Steinbüchel. 2004. The complex structure of polyhydroxybutyrate (PHB) granules: four orthologous and paralogous phasins occur in Ralstonia eutropha. Microbiology. 150:2301-11.  PubMed

Steinbüchel, A., B. Bowien, and B. Friedrich. 2004. Ralstonia eutropha Stamm H16 - eine potentielle Zellfabrik. GenomXpress 4.04:13-14. 

Winter, G., T. Buhrke, A. K. Jones, and B. Friedrich. 2004. The role of the active site-coordinating cysteine residues in the maturation of the H₂-sensing [NiFe] hydrogenase from Ralstonia eutropha H16. Arch Microbiol. 182:138-46.  PubMed

Haumann, M., A. Porthun, T. Buhrke, P. Liebisch, W. Meyer-Klaucke, B. Friedrich, and H. Dau. 2003. Hydrogen-induced structural changes at the nickel site of the regulatory [NiFe] hydrogenase from Ralstonia eutropha detected by X-ray absorption spectroscopy. Biochemistry. 42:11004-15.  PubMed

Schwartz, E., A. Henne, R. Cramm, T. Eitinger, B. Friedrich, and G. Gottschalk. 2003. Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H₂-based lithoautotrophy and anaerobiosis. J Mol Biol. 332:369-83.  PubMed

Brecht, M., M. van Gastel, T. Buhrke, B. Friedrich, and W. Lubitz. 2003. Direct detection of a hydrogen ligand in the [NiFe] center of the regulatory H₂-sensing hydrogenase from Ralstonia eutropha in its reduced state by HYSCORE and ENDOR spectroscopy. J Am Chem Soc. 125:13075-83.  PubMed

Friedrich, B. 2003. Regulatory networks in prokaryotes: variations on a theme, p. 1-3. In P. Dürre and B. Friedrich (ed.), Regulatory networks in prokaryotes. Horizon Scientific Press.

Friedrich, B., O. Lenz, T. Burgdorf, and T. Buhrke. 2003. [NiFe] hydrogenases under aerobic conditions. J Inorg Biochem. 96:46. 

Lenz, O., M. Bernhard, T. Buhrke, E. Schwartz, and B. Friedrich. 2003. The hydrogen-sensing apparatus in Ralstonia eutropha, p. 85-92. In P. Dürre and B. Friedrich (ed.), Regulatory networks in prokaryotes. Horizon Scientific Press, Wymondham, England.

Schwartz, E., and B. Friedrich. 2003. The H₂-metabolizing prokaryotes. In M. Dworkin, S. Falkow, E. Rosenberg, K. H. Schleifer, and E. Stackebrandt (ed.), The prokaryotes: an evolving electronic resource for the microbiological community, Release 3.14, 3rd ed. Springer, New York.

Burgdorf, T., A. L. De Lacey, and B. Friedrich. 2002. Functional analysis by site-directed mutagenesis of the NAD⁺-reducing hydrogenase from Ralstonia eutropha. J Bacteriol. 184:6280-8.  PubMed

Friedrich, B. 2002. Regulatory networks in prokaryotes: variations on a theme. J Mol Microbiol Biotechnol. 4:171-3.  PubMed

Lenz, O., M. Bernhard, T. Buhrke, E. Schwartz, and B. Friedrich. 2002. The hydrogen-sensing apparatus in Ralstonia eutropha. J Mol Microbiol Biotechnol. 4:255-62.  PubMed

Buhrke, T., M. Brecht, W. Lubitz, and B. Friedrich. 2002. The H₂ sensor of Ralstonia eutropha: biochemical and spectroscopic analysis of mutant proteins modified at a conserved glutamine residue close to the [NiFe] active site. J Biol Inorg Chem. 7:897-908.  PubMed

Büsch, A., B. Friedrich, and R. Cramm. 2002. Characterization of the norB gene, encoding nitric oxide reductase, in the nondenitrifying cyanobacterium Synechocystis sp. strain PCC6803. Appl Environ Microbiol. 68:668-72.  PubMed

Degen, O., and T. Eitinger. 2002. Substrate specificity of nickel/cobalt permeases: insights from mutants altered in transmembrane domains I and II. J Bacteriol. 184:3569-77.  PubMed

Lubitz, W., M. Brecht, S. Foerster, M. Stein, Y. Higuchi, T. Buhrke, and B. Friedrich. 2002. EPR and theoretical investigations of [NiFe] hydrogenase: insights into the mechanism of biological hydrogen conversion, p. 437-445. In A. Kawamori, J. Yamauchi, and H. Ohta (ed.), EPR in the 21st century. Elsevier Science, Amsterdam.

Porthun, A., M. Bernhard, and B. Friedrich. 2002. Expression of a functional NAD-reducing [NiFe] hydrogenase from the gram-positive Rhodococcus opacus in the gram-negative Ralstonia eutropha. Arch Microbiol. 177:159-66.  PubMed

Bernhard, M., T. Buhrke, B. Bleijlevens, A. L. De Lacey, V. M. Fernandez, S. P. Albracht, and B. Friedrich. 2001. The H₂ sensor of Ralstonia eutropha. Biochemical characteristics, spectroscopic properties, and its interaction with a histidine protein kinase. J Biol Chem. 276:15592-7.  PubMed

Schwartz, E., and B. Friedrich. 2001. A physical map of the megaplasmid pHG1, one of three genomic replicons in Ralstonia eutropha H16. FEMS Microbiol Lett. 201:213-9.  PubMed

Buhrke, T., B. Bleijlevens, S. P. Albracht, and B. Friedrich. 2001. Involvement of hyp gene products in maturation of the H₂-sensing [NiFe] hydrogenase of Ralstonia eutropha. J Bacteriol. 183:7087-93.  PubMed

Nishihara, H., Y. Miyata, Y. Miyashita, M. Bernhard, A. Pohlmann, B. Friedrich, and Y. Takamura. 2001. Analysis of the molecular species of hydrogenase in the cells of an obligately chemolithoautotrophic, marine hydrogen-oxidizing bacterium, Hydrogenovibrio marinus. Biosci Biotechnol Biochem. 65:2780-4.  PubMed

Eitinger, T. 2001. Microbial Nickel Transport. In G. Winkelmann (ed.), Microbial Transport Systems. Wiley-VCH, Weinheim.

Friedrich, B., P. M. Vignais, O. Lenz, and A. Colbeau. 2001. Regulation of hydrogenase gene expression, p. 73-92. In R. Cammack, M. Frey, and R. Robson (ed.), Hydrogen as a fuel. Taylor & Francis, London.

Lenz, O., and B. Friedrich. 2001. Bakterielle Wasserstoff-Sensoren. BIOspektrum 6:515-20. 

Pohlmann, A., R. Cramm, K. Schmelz, and B. Friedrich. 2000. A novel NO-responding regulator controls the reduction of nitric oxide in Ralstonia eutropha. Mol Microbiol. 38:626-38.  PubMed

Kleihues, L., O. Lenz, M. Bernhard, T. Buhrke, and B. Friedrich. 2000. The H₂ sensor of Ralstonia eutropha is a member of the subclass of regulatory [NiFe] hydrogenases. J Bacteriol. 182:2716-24.  PubMed

Happe, R. P., W. Roseboom, G. Egert, C. G. Friedrich, C. Massanz, B. Friedrich, and S. P. Albracht. 2000. Unusual FTIR and EPR properties of the H₂-activating site of the cytoplasmic NAD-reducing hydrogenase from Ralstonia eutropha. FEBS Lett. 466:259-63.  PubMed

Bernhard, M., B. Friedrich, and R. A. Siddiqui. 2000. Ralstonia eutropha TF93 is blocked in tat-mediated protein export. J Bacteriol. 182:581-8.  PubMed

Eitinger, T. 2000. Mikrobielle Transporter für Ni²⁺-Ionen. BIOspektrum 6:456. 

Eitinger, T., O. Degen, U. Böhnke, and M. Müller. 2000. Nic1p, a relative of bacterial transition metal permeases in Schizosaccharomyces pombe, provides nickel ion for urease biosynthesis. J Biol Chem. 275:18029-33.  PubMed

Eitinger, T., and M. A. Mandrand-Berthelot. 2000. Nickel transport systems in microorganisms. Arch Microbiol. 173:1-9.  PubMed

Schwartz, E., T. Buhrke, U. Gerischer, and B. Friedrich. 1999. Positive transcriptional feedback controls hydrogenase expression in Alcaligenes eutrophus H16. J Bacteriol. 181:5684-92.  PubMed

Massanz, C., and B. Friedrich. 1999. Amino acid replacements at the H₂-activating site of the NAD-reducing hydrogenase from Alcaligenes eutrophus. Biochemistry. 38:14330-7.  PubMed

Cramm, R., A. Pohlmann, and B. Friedrich. 1999. Purification and characterization of the single-component nitric oxide reductase from Ralstonia eutropha H16. FEBS Lett. 460:6-10.  PubMed

Siedow, A., R. Cramm, R. A. Siddiqui, and B. Friedrich. 1999. A megaplasmid-borne anaerobic ribonucleotide reductase in Alcaligenes eutrophus H16. J Bacteriol. 181:4919-28.  PubMed

Degen, O., M. Kobayashi, S. Shimizu, and T. Eitinger. 1999. Selective transport of divalent cations by transition metal permeases: the Alcaligenes eutrophus HoxN and the Rhodococcus rhodochrous NhlF. Arch Microbiol. 171:139-45.  PubMed

Lenz, O., and B. Friedrich. 1998. A novel multicomponent regulatory system mediates H₂ sensing in Alcaligenes eutrophus. Proc Natl Acad Sci USA. 95:12474-9.  PubMed

Pierik, A. J., M. Schmelz, O. Lenz, B. Friedrich, and S. P. Albracht. 1998. Characterization of the active site of a hydrogen sensor from Alcaligenes eutrophus. FEBS Lett. 438:231-5.  PubMed

Massanz, C., S. Schmidt, and B. Friedrich. 1998. Subforms and in vitro reconstitution of the NAD-reducing hydrogenase of Alcaligenes eutrophus. J Bacteriol. 180:1023-9.  PubMed

Schwartz, E., U. Gerischer, and B. Friedrich. 1998. Transcriptional regulation of Alcaligenes eutrophus hydrogenase genes. J Bacteriol. 180:3197-204.  PubMed

Buhrke, T., and B. Friedrich. 1998. hoxX (hypX) is a functional member of the Alcaligenes eutrophus hyp gene cluster. Arch Microbiol. 170:460-3.  PubMed

Friedrich, B. 1998. Ein Leben mit molekularem Wasserstoff 43. Jahrbuch der LEOPOLDINA (R3).

Lieb, C., R. A. Siddiqui, B. Hippler, D. Jahn, and B. Friedrich. 1998. The Alcaligenes eutrophus hemN gene encoding the oxygen-independent coproporphyrinogen III oxidase, is required for heme biosynthesis during anaerobic growth. Arch Microbiol. 169:52-60.  PubMed

Wolf, I., T. Buhrke, J. Dernedde, A. Pohlmann, and B. Friedrich. 1998. Duplication of hyp genes involved in maturation of [NiFe] hydrogenases in Alcaligenes eutrophus H16. Arch Microbiol. 170:451-9.  PubMed

Cramm, R., R. A. Siddiqui, and B. Friedrich. 1997. Two isofunctional nitric oxide reductases in Alcaligenes eutrophus H16. J Bacteriol. 179:6769-77.  PubMed

Lenz, O., A. Strack, A. Tran-Betcke, and B. Friedrich. 1997. A hydrogen-sensing system in transcriptional regulation of hydrogenase gene expression in Alcaligenes species. J Bacteriol. 179:1655-63.  PubMed

Eitinger, T., L. Wolfram, O. Degen, and C. Anthon. 1997. A Ni²⁺ binding motif is the basis of high affinity transport of the Alcaligenes eutrophus nickel permease. J Biol Chem. 272:17139-44.  PubMed

Rees, E., R. A. Siddiqui, F. Köster, B. Schneider, and B. Friedrich. 1997. Structural gene (nirS) for the cytochrome cd₁ nitrite reductase of Alcaligenes eutrophus H16. Appl Environ Microbiol. 63:800-2.  PubMed

Bernhard, M., B. Benelli, A. Hochkoeppler, D. Zannoni, and B. Friedrich. 1997. Functional and structural role of the cytochrome b subunit of the membrane-bound hydrogenase complex of Alcaligenes eutrophus H16. Eur J Biochem. 248:179-86.  PubMed

Eitinger, T., and B. Friedrich. 1997. Microbial nickel transport and incorporation into hydrogenases, p. 235-256. In G. Winkelmann and C. Carrano (ed.), Transition Metals in Microbial Metabolism. Harwood Academic Publishers, Amsterdam.

Eitinger, T., L. Wolfram, J. Dernedde, I. Wolf, N. Patenge, and B. Friedrich. 1997. Nickel metabolism in Alcaligenes eutrophus: uptake by a Ni²⁺-specific permease and metal insertion into the hydrogenases, p. 37-50. In A. X. Trautwein (ed.), Deutsche Forschungsgemeinschaft, bioinorganic chemistry, transition metals in biology and their coordination chemistry. Wiley-VCH, Weinheim.

Friedrich, B. 1997. Wasserstoff: Eine früh verfügbare Energiequelle der biochemischen Evolution, p. 9-22, Berlin-Brandenburgische Akademie der Wissenschaften, Berichte & Abhandlungen, vol. 4. Akademie Verlag, Berlin.

Massanz, C., V. M. Fernandez, and B. Friedrich. 1997. C-terminal extension of the H₂-activating subunit, HoxH, directs maturation of the NAD-reducing hydrogenase in Alcaligenes eutrophus. Eur J Biochem. 245:441-8.  PubMed

Hole, U. H., K. U. Vollack, W. G. Zumft, E. Eisenmann, R. A. Siddiqui, B. Friedrich, and P. M. Kroneck. 1996. Characterization of the membranous denitrification enzymes nitrite reductase (cytochrome cd₁) and copper-containing nitrous oxide reductase from Thiobacillus denitrificans. Arch Microbiol. 165:55-61.  PubMed

Thiemermann, S., J. Dernedde, M. Bernhard, W. Schroeder, C. Massanz, and B. Friedrich. 1996. Carboxyl-terminal processing of the cytoplasmic NAD-reducing hydrogenase of Alcaligenes eutrophus requires the hoxW gene product. J Bacteriol. 178:2368-74.  PubMed

Bernhard, M., E. Schwartz, J. Rietdorf, and B. Friedrich. 1996. The Alcaligenes eutrophus membrane-bound hydrogenase gene locus encodes functions involved in maturation and electron transport coupling. J Bacteriol. 178:4522-9.  PubMed

Dernedde, J., T. Eitinger, N. Patenge, and B. Friedrich. 1996. hyp gene products in Alcaligenes eutrophus are part of a hydrogenase-maturation system. Eur J Biochem. 235:351-8.  PubMed

Friedrich, B., M. Bernhard, J. Dernedde, T. Eitinger, O. Lenz, C. Massanz, and E. Schwartz. 1996. Hydrogen oxidation by Alcaligenes eutrophus, p. 110-117. In M. E. Lidstrom and F. R. Tabita (ed.), Microbial Growth on C₁ Compounds. Kluwer Academic Publishers, Dordrecht, The Netherlands.

Ermler, U., R. A. Siddiqui, R. Cramm, and B. Friedrich. 1995. Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 Å resolution. Embo J. 14:6067-77.  PubMed

Ermler, U., R. A. Siddiqui, R. Cramm, D. Schröder, and B. Friedrich. 1995. Crystallization and preliminary X-ray diffraction studies of a bacterial flavohemoglobin protein. Proteins. 21:351-3.  PubMed

Eitinger, T., L. Wolfram, and B. Friedrich. 1995. Molecular characterization of the Alcaligenes eutrophus nickel permease J Inorg Biochem. 59:644. 

Wolfram, L., B. Friedrich, and T. Eitinger. 1995. The Alcaligenes eutrophus protein HoxN mediates nickel transport in Escherichia coli. J Bacteriol. 177:1840-3.  PubMed

Zimmer, D., E. Schwartz, A. Tran-Betcke, P. Gewinner, and B. Friedrich. 1995. Temperature tolerance of hydrogenase expression in Alcaligenes eutrophus is conferred by a single amino acid exchange in the transcriptional activator HoxA. J Bacteriol. 177:2373-80.  PubMed

Cramm, R., R. A. Siddiqui, and B. Friedrich. 1994. Primary sequence and evidence for a physiological function of the flavohemoprotein of Alcaligenes eutrophus. J Biol Chem. 269:7349-54.  PubMed

Lenz, O., E. Schwartz, J. Dernedde, M. Eitinger, and B. Friedrich. 1994. The Alcaligenes eutrophus H16 hoxX gene participates in hydrogenase regulation. J Bacteriol. 176:4385-93.  PubMed

Eitinger, T., and B. Friedrich. 1994. A topological model for the high-affinity nickel transporter of Alcaligenes eutrophus. Mol Microbiol. 12:1025-32.  PubMed

Sann, R., S. Kostka, and B. Friedrich. 1994. A cytochrome cd₁-type nitrite reductase mediates the first step of denitrification in Alcaligenes eutrophus. Arch Microbiol. 161:453-9.  PubMed

Siddiqui, R. A., U. Warnecke-Eberz, A. Hengsberger, B. Schneider, S. Kostka, and B. Friedrich. 1993. Structure and function of a periplasmic nitrate reductase in Alcaligenes eutrophus H16. J Bacteriol. 175:5867-76.  PubMed

Dernedde, J., M. Eitinger, and B. Friedrich. 1993. Analysis of a pleiotropic gene region involved in formation of catalytically active hydrogenases in Alcaligenes eutrophus H16. Arch Microbiol. 159:545-53.  PubMed

Friedrich, B., and E. Schwartz. 1993. Molecular biology of hydrogen utilization in aerobic chemolithotrophs. Annu Rev Microbiol. 47:351-83.  PubMed

Warnecke-Eberz, U., and B. Friedrich. 1993. Three nitrate reductase activities in Alcaligenes eutrophus. Arch Microbiol. 159:405-409. 

Kömen, R., K. Schmidt, and B. Friedrich. 1992. Hydrogenase mutants of Alcaligenes eutrophus H16 show alterations in the electron transport system. FEMS Microbiol Lett. 75:173-8.  PubMed

Kortlüke, C., and B. Friedrich. 1992. Maturation of membrane-bound hydrogenase of Alcaligenes eutrophus H16. J Bacteriol. 174:6290-3.  PubMed

Kortlüke, C., K. Horstmann, E. Schwartz, M. Rohde, R. Binsack, and B. Friedrich. 1992. A gene complex coding for the membrane-bound hydrogenase of Alcaligenes eutrophus H16. J Bacteriol. 174:6277-89.  PubMed

Rensing, C., U. Kues, U. Stahl, D. H. Nies, and B. Friedrich. 1992. Expression of bacterial mercuric ion reductase in Saccharomyces cerevisiae. J Bacteriol. 174:1288-92.  PubMed

Warrelmann, J., M. Eitinger, E. Schwartz, D. Römermann, and B. Friedrich. 1992. Nucleotide sequence of the rpoN (hno) gene region of Alcaligenes eutrophus: evidence for a conserved gene cluster. Arch Microbiol. 158:107-14.  PubMed

Zumft, W. G., A. Dreusch, S. Löchelt, H. Cuypers, B. Friedrich, and B. Schneider. 1992. Derived amino acid sequences of the nosZ gene (respiratory N₂O reductase) from Alcaligenes eutrophus, Pseudomonas aeruginosa and Pseudomonas stutzeri reveal potential copper-binding residues. Implications for the Cu_A site of N₂O reductase and cytochrome-c oxidase. Eur J Biochem. 208:31-40.  PubMed

Dressler, C., U. Kues, D. H. Nies, and B. Friedrich. 1991. Determinants Encoding Resistance to Several Heavy Metals in Newly Isolated Copper-Resistant Bacteria. Appl Environ Microbiol. 57:3079-3085.  PubMed

Hanski, C., M. Naumann, A. Grutzkau, G. Pluschke, B. Friedrich, H. Hahn, and E. O. Riecken. 1991. Humoral and cellular defense against intestinal murine infection with Yersinia enterocolitica. Infect Immun. 59:1106-11.  PubMed

Eberz, G., and B. Friedrich. 1991. Three trans-acting regulatory functions control hydrogenase synthesis in Alcaligenes eutrophus. J Bacteriol. 173:1845-54.  PubMed

Eitinger, T., and B. Friedrich. 1991. Cloning, nucleotide sequence, and heterologous expression of a high-affinity nickel transport gene from Alcaligenes eutrophus. J Biol Chem. 266:3222-7.  PubMed

Wolfram, L., T. Eitinger, and B. Friedrich. 1991. Construction and properties of a triprotein containing the high-affinity nickel transporter of Alcaligenes eutrophus. FEBS Lett. 283:109-12.  PubMed

Hornhardt, S., K. Schneider, B. Friedrich, B. Vogt, and H. G. Schlegel. 1990. Identification of distinct NAD-linked hydrogenase protein species in mutants and nickel-deficient wild-type cells of Alcaligenes eutrophus H16. Eur J Biochem. 189:529-37.  PubMed

Tran-Betcke, A., U. Warnecke, C. Böcker, C. Zaborosch, and B. Friedrich. 1990. Cloning and nucleotide sequences of the genes for the subunits of NAD-reducing hydrogenase of Alcaligenes eutrophus H16. J Bacteriol. 172:2920-9.  PubMed

Bender, R. A., and B. Friedrich. 1990. Regulation of assimilatory nitrate reductase formation in Klebsiella aerogenes W70. J Bacteriol. 172:7256-9.  PubMed

Friedrich, B. 1990. The plasmid-encoded hydrogenase gene cluster in Alcaligenes eutrophus. FEMS Microbiol Rev. 87:425-430. 

Friedrich, B., C. Böcker, G. Eberz, T. Eitinger, K. Horstmann, C. Kortlüke, D. Römermann, E. Schwartz, A. Tran-Betcke, U. Warnecke, and J. Warrelmann. 1990. Genes for hydrogen oxidation and denitrification form two clusters on megaplasmid pHG1 of Alcaligenes eutrophus, p. 408-419. In S. Silver (ed.), Pseudomonas: Biotransformations, Pathogenesis and Evolving Biotechnology. American Society for Microbiology, Washington, DC.

Friedrich, B., and C. G. Friedrich. 1990. Hydrogenases in lithoautotrophic bacteria, p. 55-92. In G. A. Codd, L. Dijkhuizen, and F. R. Tabita (ed.), Advances in autotrophic microbiology and one carbon-metabolism. Kluwer Academic Publishers, Dordrecht, The Netherlands.

Friedrich, B., U. Warnecke, R. Sann, and B. Schneider. 1990. Presented at the 5th European Congress on Biotechnology, Copenhagen.

Fiebig, K., and B. Friedrich. 1989. Purification of the F₄₂₀-reducing hydrogenase from Methanosarcina barkeri (strain Fusaro). Eur J Biochem. 184:79-88.  PubMed

Römermann, D., J. Warrelmann, R. A. Bender, and B. Friedrich. 1989. An rpoN-like gene of Alcaligenes eutrophus and Pseudomonas facilis controls expression of diverse metabolic pathways, including hydrogen oxidation. J Bacteriol. 171:1093-9.  PubMed

Eberz, G., T. Eitinger, and B. Friedrich. 1989. Genetic determinants of a nickel-specific transport system are part of the plasmid-encoded hydrogenase gene cluster in Alcaligenes eutrophus. J Bacteriol. 171:1340-5.  PubMed

Friedrich, B. 1989. Genetics of energy converting systems in aerobic chemolithotrophs, p. 415-436. In H. G. Schlegel and B. Bowien (ed.), Biology of autotrophic bacteria. Science Tech Publishers/Heidelberg, Madison/Heidelberg.

Warrelmann, J., and B. Friedrich. 1989. Genetic transfer of lithoautotrophy mediated by a plasmid-cointegrate from Pseudomonas facilis. Arch Microbiol. 151:359-364. 

Warrelmann, J., and B. Friedrich. 1989. Large plasmids in wild type strains of Pseudomonas  facilis. Endocytobiosis and Cell Res. 2:213-217. 

Weihs, V., K. Schmidt, B. Schneider, and B. Friedrich. 1989. The formation of an oxygen-binding flavohemoprotein in Alcaligenes eutrophus  is plasmid-determined. Arch Microbiol. 151:546-550. 

Schneider, B., A. Nies, and B. Friedrich. 1988. Transfer and expression of lithoautotrophy and denitrification in a host lacking these metabolic activities. Appl Environ Microbiol. 54:3173-3176.  PubMed

Römermann, D., M. Lohmeyer, C. G. Friedrich, and B. Friedrich. 1988. Pleiotropic mutants from Alcaligenes eutrophus  defective in the metabolism of hydrogen, nitrate, urea and fumarate. Arch Microbiol. 149:471-475. 

Nies, D., M. Mergeay, B. Friedrich, and H. G. Schlegel. 1987. Cloning of plasmid genes encoding resistance to cadmium, zinc, and cobalt in Alcaligenes eutrophus CH34. J Bacteriol. 169:4865-8.  PubMed

Friedrich, B. 1987. Genetics of aerobic lithoautotrophs, p. 230-237. In H. W. Van Verseveld and J. A. Duine (ed.), Microbial Growth on C₁ compounds. Nijhoff Publishers, Dordrecht, The Netherlands.

Friedrich, B. 1987. Gentechnologie: Mikroorganismen als Werkzeuge im Dienst des Menschen, p. 73-94. In C. Niemitz (ed.), Erbe und Umwelt - Zur Natur von Anlage und Selbstbestimmung des Menschen, vol. 646. Suhrkamp Taschenbuch Wissenschaft, Frankfurt a. M.

Kortlüke, C., C. Hogrefe, G. Eberz, A. Pühler, and B. Friedrich. 1987. Genes of lithoautotrophic metabolism are clustered on the megaplasmid pHG1 in Alcaligenes eutrophus. Mol Gen Genet. 210:122-128. 

Eberz, G., C. Hogrefe, C. Kortlüke, A. Kamienski, and B. Friedrich. 1986. Molecular cloning of structural and regulatory hydrogenase (hox) genes of Alcaligenes eutrophus H16. J Bacteriol. 168:636-41.  PubMed

Friedrich, B., C. Kortlüke, C. Hogrefe, G. Eberz, B. Silber, and J. Warrelmann. 1986. Genetics of hydrogenase from aerobic lithoautotrophic bacteria. Biochimie. 68:133-45.  PubMed

Warrelmann, J., and B. Friedrich. 1986. Mutants of Pseudomonas facilis  defective in lithoautotrophy. J Gen Microbiol. 132:91-96. 

Römermann, D., and B. Friedrich. 1985. Denitrification by Alcaligenes eutrophus is plasmid dependent. J Bacteriol. 162:852-4.  PubMed

Friedrich, B. 1985. Evolution of chemolithoautotrophy, p. 205-234. In K. H. Schleifer and E. Stackebrandt (ed.), Evolution of Prokaryotes. Academic Press, London.

Friedrich, B. 1985. Unkonventionelle Stoffwechselwege in Bakterien werden durch Riesenplasmide kodiert. Sitzungsberichte der Gesellschaft Naturforschender Freunde zu Berlin. p. 127-144.

Hogrefe, C., and B. Friedrich. 1984. Isolation and characterization of megaplasmid DNA from lithoautotrophic bacteria. Plasmid. 12:161-9.  PubMed

Friedrich, B., C. G. Friedrich, M. Meyer, and H. G. Schlegel. 1984. Expression of hydrogenase in Alcaligenes spp. is altered by interspecific plasmid exchange. J Bacteriol. 158:331-3.  PubMed

Hogrefe, C., D. Römermann, and B. Friedrich. 1984. Alcaligenes eutrophus hydrogenase genes (hox). J Bacteriol. 158:43-8.  PubMed

Bowien, B., B. Friedrich, and C. G. Friedrich. 1984. Involvement of megaplasmids in heterotrophic derepression of the carbon-dioxide assimilating enzyme system in Alcaligenes spp. Arch Mikrobiol. 139:305-310. 

Friedrich, B., and C. Hogrefe. 1984. Genetics of lithoautotrophic metabolism in Alcaligenes eutrophus, p. 244 -247. In R. L. Crawford and R. S. Hanson (ed.), Microbial Growth on C₁ compounds. American Society for Microbiology, Washington, DC.

Friedrich, C. G., and B. Friedrich. 1983. Regulation of hydrogenase formation is temperature sensitive and plasmid coded in Alcaligenes eutrophus. J Bacteriol. 153:176-81.  PubMed

Friedrich, B., M. Meyer, and H. G. Schlegel. 1983. Transfer and expression of the herbicide-degrading plasmid pJP4 in aerobic autotrophic bacteria. Arch Microbiol. 134:92-7.  PubMed

Friedrich, C. G., K. Schneider, and B. Friedrich. 1982. Nickel in the catalytically active hydrogenase of Alcaligenes eutrophus. J Bacteriol. 152:42-8.  PubMed

Srivastava, S., M. Urban, and B. Friedrich. 1982. Mutagenesis of Alcaligenes eutrophus by insertion of the drug-resistance transposon Tn5. Arch Mikrobiol. 131:203-7.  PubMed

Schlesier, M., and B. Friedrich. 1982. Effect of molecular hydrogen on histidine utilization by Alcaligenes eutrophus. Arch Microbiol. 132:260-265.  PubMed

Gerstenberg, C., B. Friedrich, and H. G. Schlegel. 1982. Physical evidence for plasmids in autotrophic, especially hydrogen-oxidizing bacteria. Arch Microbiol. 133:90-96.  PubMed  

Schlesier, M., and B. Friedrich. 1982. Histidine utilization by Alcaligenes eutrophus: regulation of histidase formation under heterotrophic conditions of growth. Arch Microbiol. 132:254-259. 

Friedrich, B., E. Heine, A. Finck, and C. G. Friedrich. 1981. Nickel requirement for active hydrogenase formation in Alcaligenes eutrophus. J Bacteriol. 145:1144-9.  PubMed

Friedrich, B., C. Hogrefe, and H. G. Schlegel. 1981. Naturally occurring genetic transfer of hydrogen-oxidizing ability between strains of Alcaligenes eutrophus. J Bacteriol. 147:198-205.  PubMed

Schlesier, M., and B. Friedrich. 1981. In vivo inactivation of soluble hydrogenase of Alcaligenes eutrophus. Arch Microbiol. 129:150-3.  PubMed

Friedrich, C. G., B. Friedrich, and B. Bowien. 1981. Formation of enzymes of autotrophic metabolism during heterotrophic growth of Alcaligenes eutrophus. J Gen Microbiol. 122:69-78. 

Schlegel, H. G., M. E. K. Ibrahim, E. Wilde, K. Schneider, M. Schlesier, B. Friedrich, and K. A. Malik. 1981. Detrimental and beneficial effects of oxygen exerted on hydrogen-oxidizing bacteria, p. 107-129. In J. M. Lyons, R. C. Valentine, D. A. Phillips, D. W. Rains, and R. C. Huffaker (ed.), Genetic engineering of symbiotic nitrogen fixation, vol. 17. Plenum Press, New York.

Friedrich, B., and B. Magasanik. 1979. Enzymes of agmatine degradation and the control of their synthesis in Klebsiella aerogenes. J Bacteriol. 137:1127-33.  PubMed

Friedrich, C. G., B. Bowien, and B. Friedrich. 1979. Formate and oxalate metabolism in Alcaligenes eutrophus. J Gen Microbiol. 115:185-192. 

Friedrich, B., C. G. Friedrich, and B. Magasanik. 1978. Catabolic N²-acetylornithine 5-aminotransferase of Klebsiella aerogenes: control of synthesis by induction, catabolite repression, and activation by glutamine synthetase. J Bacteriol. 133:686-91.  PubMed

Friedrich, B., and B. Magasanik. 1978. Utilization of arginine by Klebsiella aerogenes. J Bacteriol. 133:680-5.  PubMed

Friedrich, B., and B. Magasanik. 1977. Urease of Klebsiella aerogenes: control of its synthesis by glutamine synthetase. J Bacteriol. 131:446-52.  PubMed

Friedrich, B., C. G. Friedrich, and H. G. Schlegel. 1976. Purification and properties of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus. J Bacteriol. 126:712-22.  PubMed

Friedrich, C. G., B. Friedrich, and H. G. Schlegel. 1976. Regulation of chorismate mutase-prephenate dehydratase and prephenate dehydrogenase from Alcaligenes eutrophus. J Bacteriol. 126:723-32.  PubMed

Friedrich, C. G., B. Friedrich, and H. G. Schlegel. 1976. Aromatic amino acid biosynthesis in Alcaligenes eutrophus H 16 III. Properites and regulation of anthranilate synthase. Arch Microbiol. 107:125-31.  PubMed

Friedrich, B., and H. G. Schlegel. 1975. Aromatic amino acid biosynthesis in Alcaligenes eutrophus H16. II. The isolation and characterization of mutants auxotrophic for phenylalanine and tyrosine. Arch Microbiol. 103:141-9.  PubMed

Friedrich, B., and H. G. Schlegel. 1972. [Hydroxylation of phenylalanine by Hydrogenomonas eutropha H16]. Arch Mikrobiol. 83:17-31.  PubMed