Research projects

Mathematical modeling of complex biological phenomena and diseases is an important approach to combine the accumulating amount of data in biological investigations and the increasing qualitative understanding of cellular operation in a productive way. The realization of genomic information in a biological instance is ensured by a complex network of processes. The dynamic behavior of such processes cant be understood intuitively. Only a comprehensive approach allows the understanding of complex system behavior like optimal regulation or adaptation. We use mathematical models to describe and investigate cellular processes and regulatory links from gene expression to metabolism.

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PhD programs

CSB
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Research Training Group: Computational Systems Biology
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SignGene
German-Israeli Research School "Frontiers in Cell Signaling and Gene Regulation"
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Affiliated scientists: Edda Klipp

Junior research group

e:Bio Cellemental
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The complexity of cellular networks is an outstanding challenge for documentation, visualisation and mathematical modelling. In this project, we develop a new way to describe these networks that minimises the combinatorial complexity and allows an automatic visualisation and export to mathematical models.
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DFG Sachbeihilfe

Osmotic Stress Response
Understanding the interplay between osmotic stress response and ion homeostasis in Saccharomyces cerevisiae
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Affiliated scientist: Jannis Uhlendorf

Cooperative research projects

OncoPATH
A systematic analysis of colorectal cancer
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Affiliated scientists: Timo Lubitz, Edda Klipp
SFB 740
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Collaborative Research Center:
From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells
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SysToxChip
Design of multi-organ chips to test toxicities of xenobiotics on human liver and kidney
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Affiliated scientists: Judith Wodke, Edda Klipp
ViroSign
Systemvirologie von Influenza - Molekulare Signatur der permissiven Virusinfektion
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Finished research projects

Aquaglyceroporins
Marie Curie Research Training Network:
Integrate Analysis of Aquaporin Structure and Function
BaSysBio
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Developing 'Systems Biology' Techniques to Study the Global Regulation of Gene Transcription in a Model Bacterium: Bacillus subtilis
CellComput
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ColoNET
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A Systems Biology Approach for Integrating Molecular Diagnostics and Targeted Therapy in Colorectal Cancer
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Affiliated scientists: (Thomas Handorf), (Edda Klipp)
Drug-iPS
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Gene Regulation and Stem Cell Research
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Einstein Research Network "RNA"
Single Molecule RNA Biology - Dynamics and function of RNA from transcription to degradation
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Affiliated scientists: (Severin Ehret), (Edda Klipp)
EMI-CD
European Modelling Initiative Combating Complex Diseases
ENFIN
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Enabling Systems Biology
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EST Systems Biology
Marie Curie Early Stage Training in Systems Biology:
Mathematical Modeling of Aging Processes in Yeast
FinSysB
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Marie Curie Initial Training Network:
Pathogenomics and Systems Biology of Fungal Infections - An Integrative Approach
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Affiliated scientists: (Katarzyna Tyc), (Edda Klipp)
GerontoMitoSys
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Mitochondrial network of pathways in aging and lifespan control - a systems biology approach
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IMPRS
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International Max Planck Research School
for Computational Biology and Scientific Computing
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IRTG
International Research Training Group: Berlin - Boston - Kyoto
Genomics and Systems Biology of Molecular Networks
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LGS Molecular Biophysics
Leibniz Graduate School of Molecular Biophysics
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Affiliated scientists: (Matthias Reis), (Edda Klipp)
Quasi
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Mathematical Modeling of Stress Response and Signal Transduction in Yeast
SFB 618
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Collaborative Research Center for
Theoretical Biology: Robustness, Modularity and Evolutionary Design of Living Systems
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Affiliated scientists: (Marvin Schulz), (Edda Klipp)
SysteMTb
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A Collaborative Project for the Establishment of a Systems Biology Framework to Understand Key Features of Mycobacterium Tuberculosis
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Translucent 1
Systems Biology of Micro Organisms: Gene Interaction Networks and Models of Cation Homeostasis in Saccharomyces cerevisiae
Translucent-2
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Modelling Ion Homeostasis in the Yeast Saccharomyces cerevisiae
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UNICELLSYS
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Eukaryotic Unicellular Organism Biology – Systems Biology of the Control of Cell Growth and Proliferation
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YSBN
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The Yeast Systems Biology Network
Affiliated scientists: (Thomas Spießer), (Edda Klipp)