Prof. Dr. Christoph Arenz
Publications
1999
C. Arenz, A. Giannis, Design and Synthesis of Modulators of Sphingolipid Biosynthesis in U. Diederichsen et. Al. (Ed.) "Bioorganic Chemistry,Highlights and New Aspects", Wiley-VCH, Weinheim, 1999, 225-231.
2000
C. Arenz, A. Giannis, Synthesis of the First Selective Irreversible Inhibitor of Neutral Sphingomyelinase Angew. Chem. 2000, 112, 1498-1500; Angew. Chem. Int. Ed. 2000, 39, 1440-1442.
2001
C. Arenz, A. Giannis, Synthesis of the First Selective Irreversible Inhibitor of Neutral Sphingomyelinase Eur. J. Org. Chem. 2001, 1, 137-140.
C. Arenz, M. Thutewohl, O. Block, H. Waldmann, H.-J. Altenbach, A. Giannis, Manumycin A and its Analogues Are Irreversible Inhibitors of Neutral Sphingomyelinase ChemBioChem 2001, 2, 141-143.
C. Arenz, M. Gartner V. Wascholowski, A. Giannis, Synthesis and Biological Investigation of Scyphostatin Analogues as Inhibitors of Neutral Sphingomyelinase Bioorg. Med. Chem. 2001, 11, 2901-4.
2003
M. Diallo, C. Arenz, K. Schmitz, K. Sandhoff, U. Schepers, RNA Interference: A new method to analyze the function of glycoproteins and glycosylating proteins. Knockout experiments with UDP-glucose/ceramide glucosyl-transferase as an example for its general application. Meth. Enzymol. 2003, 363, 173-190.
C. Arenz, U. Schepers, RNA Interference: from an ancient mechanism to a state of the art therapeutic application? Naturwissenschaften 2003, 90, 345-359.
M. Kölzer, C. Arenz, K. Ferlinz, N. Werth, S. Lansmann, K. Sandhoff, The newly discovered cellular signalling molecule is a potent inhibitor of acid Sphingomyelinase Biol. Chem. 2003, 384, 1293-1298.
M. Diallo, C. Arenz, K. Schmitz, K. Sandhoff, U. Schepers, Long endogenous dsRNA can induce complete gene silencing in mammalian cells and primary cultures Oligonucleotides 2003, 13, 357-363.
Published conference contributions
C. Arenz, A. Cryns, M. Diallo, K. Sandhoff, U. Schepers, Analysis of skin glycosphingolipid metabolism by RNA interference in transgenic mice, Eur. J. Cell Biol. 2003, 82, 97.
M. Diallo, C. Arenz, K. Schmitz, K. Sandhoff, U. Schepers, Stable post transcriptional gene silencing of glucosylceramide-synthase by RNA interference in human cells, Eur. J. Cell Biol. 2003, 82, 98.
K. Schmitz, C. Arenz, M. Diallo, A. Cryns, S. Hoffman, K. Sandhoff, U. Schepers, New approaches to study protein function in mammalian cells and organisms, Eur. J. Cell Biol. 2003, 82, 99-100.
K. Schmitz, M. Diallo, C. Arenz, R. Mundegar, K. Sandhoff, U. Schepers, Synthesis of a new carrier-system for transduction of siRNAs into cells for the local transient posttranscriptional gene silencing in mammals, Eur. J. Cell Biol. 2003, 82, 100.
2006
C. Arenz "Peptidnukleinsäuren in der Biomedizin" (Trendbericht 2005) Nachr. Chem. 2006, 54, 270-273.
C. Arenz "MicroRNAs - zukünftige Wirkstoff-Targets?" (Highlight) Angew. Chem. 2006, 118, 5170-5172.
B. P. Davies, C. Arenz "Ein homogener Assay der microRNA-Reifung" Angew. Chem. 2006, 118, 5676-5679.
2007
J. O. Babalola, M. Wendeler, B. Breiden, C. Arenz, G. Schwarzmann, S. Locatelli-Hoops, K. Sandhoff
"Development of an Assay for the Intermembrane Transfer of Cholesterol by Niemann-Pick C2 Protein" Biol. Chem. 2007, 388, 617-626.C. Arenz, O. Seitz "DNA Made of Purines Only" (Preview) Chem. Biol. 2007, 14, 467-469.
2008
B. P. Davies, C. Arenz "A Fluorescence Probe for Assaying micro RNA maturation" Bioorg. Med. Chem. 2008, 16, 49-55.
2009
C. M. Klemm, A. Berthelmann, S. Neubacher, C. Arenz
"Short and Efficient Synthesis of Alkyne-Modified Aminoglycoside Building Blocks"
Eur. J. Org. Chem. 2009, 17, 2788-2794.S. Neubacher, C. Arenz "Rolling Circle Amplification: Unshared Advantages in miRNA Detection"
ChemBioChem. 2009, 10 (8), 1289-1291.Anke G. Roth, S. Redmer, C. Arenz "Potent Inhibition of Acid Sphingomyelinase by Phosphoinositide Analogues"
ChemBioChem. 2009, 2367-2374.A. G. Roth, D. Drescher, Y. Yang, S. Redmer, S. Uhlig, C. Arenz "Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates"
Angew. Chem. Int. Ed. 2009, 7560-7563.A. G. Roth, D. Drescher, Y. Yang, S. Redmer, S. Uhlig, C. Arenz "Potente und selektive Inhibition der sauren Sphingomyelinase durch Bisphosphonate"
Angew. Chem. 2009, 7697-7700.
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