Dr. rer. nat. Essa M. Saied

Publications

2021

E. M. Saied and C.Arenz*
"Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx"
Int J Mol Sci 2021, accepted.

T.C.B. Santos, E.M. Saied, C. Arenz, A. Fedorov, M. Prieto, L.C. Silva*
"The long chain base unsaturation has a stronger impact on 1-deoxy(methyl)-sphingolipids biophysical properties than the structure of its C1 functional group"
BBA - Biomembranes 2021, accepted, BBAMEM-21-41R1.

Y. Otsuka, M. V. Airola, Y. M. Choi, N. Coant, J. Snider, C. Cariello, E. M. Saied, C. Arenz, T. Bannister, R. Rahaim, Jr., Y. A. Hannun, J. Shumate, L. Scampavia, J. D. Haley, T. P. Spicer*
"Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening"
SLAS Discov. 2021, in press doi:10.1177/2472555220945283

2020

D. Samaha, H.H. Hamdo, X. Cong, F. Schumacher, S. Banhart, Ö. Aglar, H. M. Möller, D. Heuer, B. Kleuser, E. M. Saied* and C. Arenz*
"A liposomal FRET assay identifies potent drug-like inhibitors of the ceramide transport protein CERT"
Chemistry - Eur J 2020, 26, 16616-16621.

M. A. Lone , A. J. Huelsmeier , E.M. Saied , G. Karsai , C. Arenz , A. von Eckardstein , T. Hornemann*
"Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases"
Proc Natl Acad Sci USA 2020, 117, 15591-15598.

T. C. B. Santos, A. Vaz, A. E. Ventura, E. M. Saied, C. Arenz, A. Fedorov, M. Prieto, L. C. Silva*
“Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties”
Langmuir 2020, 36, 6007–6016.

C. Kirschbaum, E.M. Saied, K. Greis, E. Mucha, S. Gewinner, W. Schöllkopf, G.J.M. Meijer, G. von Helden, B.L.J. Poad, S.J. Blanksby, C. Arenz* and K. Pagel*
“Resolving Sphingolipid Isomers using Cryogenic Infrared Spectroscopy”
Angew Chem 2020, 132, 13740-13744.

E. M. Saied and C.Arenz*
"Synthesis and Characterization of Novel Atypical Sphingoid Bases"
ChemRxiv 2020, DOI:10.26434/chemrxiv.12094041.v1209404.

2018

I. Vasiliauskaité-Brooks, R. D. Healey, P. Rochaix, R. Sounier, C. Grison, T. Waltrich-Augusto, M. Fortier, F. Hoh, E.M. Saied, C. Arenz, S. Basu, C. Leyrat*, S. Granier*
"Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy"
Nat.Commun. 2018 9, 5437.

Z. H. Mohamed, C. Rhein, E. M. Saied, J. Kornhuber, C. Arenz*
"FRET probes for measuring sphingolipid metabolizing enzyme activity (Review)"
Chem. Phys. Lipids 2018 accepted,DOI: 10.1016/j.chemphyslip.2018.09.014

J. Ren, E. M. Saied, A. Zhong, J. Snider, C. Ruiz, C. Arenz, L. M. Obeid, G. D. Girnun, Y. A. Hannun*
"Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in sphingolipid pathway"
J. Lipid Res. 2018 accepted, DOI: 10.1194/jlr.M088195

E. M. Saied, T. L.-S. Le, T. Hornemann and C.Arenz*
"Synthesis and Characterization of some Atypical Sphingoid Bases"
Bioorg Med Chem 2018 accepted, DOI: 10.1016/j.bmc.2018.06.031.

B. L. J. Poad*, A. T. Maccarone, H. Yu, T. W. Mitchell, E. M. Saied, C. Arenz, T. Hornemann, J. N. Bull, E. J. Bieske, S. J. Blanksby*
"Differential-mobility spectrometry of 1-deoxysphingosine isomers: new insights into the gas phase structures of ionized lipids"
Anal Chem 2018, 90, 5343–5351.

2017

L. Collenburg, N. Beyersdorf, C. Arenz, E. M. Saied, E. Avota, S. Schneider-Schaulies*
"The activity of the neutral sphingomyelinase is important in T cell recruitment and directional migration"
Front. Immunol. 2017, 8, 1007.

S. Koch-Edelmann, S. Banhart, E. M. Saied, L. Rose, L. Aeberhard, M. Laue, J. Doellinger, C. Arenz and D. Heuer*
"The cellular ceramide transport protein CERT promotes Chlamydia psittaci infection and controls bacterial sphingolipid uptake"
Cell Microbiol 2017, in press, doi: 110.1111/cmi.12752

I. Vasiliauskaité-Brooks, R. Sounier, P. Rochaix, G. Bellot, M. Fortier, F. Hoh, L. De Colibus, C. Bechara, E.M. Saied, C. Arenz, C. Leyrat*, S. Granier*
"Structural insights into adiponectin receptors suggest ceramidase activity"
Nature 2017, 544, 120-123.

M. Sharar, E.M. Saied, M. Corte, C. Arenz, M. Linscheid, M. Montes-Bayón*
"Elemental Labelling and Mass Spectrometry for the Specific Detecion of Sulfenic Acid Groups in Model Peptides: A Proof of Concept"
Anal. Bioanal. Chem. 2017, 409, 2015-2027.

I. Alecu, A. Othman, A. Penno, E.M. Saied, C. Arenz, A. von Eckardstein and T. Hornemann*
"Cytotoxic 1-Deoxysphingolipids Are Metabolized by a Cytochrome P450-Dependent Pathway"
J. Lipid Res. 2017, 58, 60-71.

2016

I. Alecu, A. Othman, A. Penno, E.M. Saied, C. Arenz, A. von Eckardstein and T. Hornemann "Cytotoxic 1-Deoxysphingolipids Are Metabolized by a Cytochrome P450-Dependent Pathway"
J. Lipid Res. 2016, in press doi:10.1194/jlr.M072421

R. Steiner*, E.M. Saied*, A. Othman, C. Arenz, A.T. Maccarone, B.L.J. Poad, S.J. Blanksby, A. von Eckardstein, T. Horneman*
"Elucidating the chemical structure of native 1-deoxysphingosine"
J. Lipid Res. 2016, 57, 1194-1203.

E. M. Saied, C. Arenz*
"Inhibitors of Ceramidases"
Chem Phys Lipids 2016, 19760-68.

2015

E. M. Saied, S. Banhart, S. E. Bürkle, D. Heuer, C. Arenz* "A Series of Ceramide Analogues Modified at the 1-Position With Potent Activity Against the Intracellular Growth of Chlamydia trachomatis"
Future Med Chem 2015, 7, 1971-1980.

2014

S. Banhart, E. M. Saied, A. Martini, S. Koch, L. Aeberhard, K. Madela, C. Arenz, and D. Heuer* "Improved plaque assay identifies a novel anti-Chlamydia ceramide derivative with altered intracellular localization"
Antimicrob. Agents Chemother. 2014, in press

E. M. Saied, C. Arenz* "Small Molecule Inhibitors of Ceramidases"
Cell Phys Biochem 2014, 34, 197-212

E. M. Saied, S. Diederich, C. Arenz* "Facile Synthesis of the CERT Inhibitor HPA-12 and Some Novel Derivatives"
Chem Asian J 2014, DOI: 10.1002/asia.201402241

2009

Moamen S. Refat, H.K. Ibrahim, S.Z.A. Sowellim, M.H. Soliman, E.M. Saied "Spectroscopic and Thermal Studies of Mn(II), Fe(III), Cr(III) and Zn(II) Complexes Derived from the Ligand Resulted by the Reaction Between 4-Acetyl Pyridine and Thiosemicarbazide"
Journal of Inorganic and Organometallic Polymers and Materials, Springer New York 2009, 19 , 521-531

S.Z.A. Sowellim, M.H. Soliman, E.M. Saied "Synthesis, Mass Spectra and Antimicrobial Activity of Thiosemicarbazone and Imidazolidinone Derivatives"
Mens Agitat 2009 V4, N2

 

Dr. rer. nat.
Essa M. Saied

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