Publications

since 2006

2024

Y. Feng, F. Gärber, E.M. Saied, C. Spedalieri, Z. Kochovski, S. Werner, C. Pratsch, C. Arenz, S. Seifert, J. Kneipp*
"SERS Spectra Indicate the Molecular Effects of 7-Nitrobenz-2-oxa-1,3-diazole (NBD) on Living Cells"
J. Phys. Chem. C 2024, just accepted, jp-2024-05260z.R1

M.-A. Kirmpaki, E.M. Saied, F. Schumacher, K. Prause, B. Kleuser and C. Arenz*
"Live-Cell Identification of Inhibitors of the Lipid Transfer Protein CERT Using Nanoluciferase Bioluminescence Resonance Energy Transfer (NanoBRET)"
Angew. Chem. 2024, just accepted,DOI: 10.1002/anie.202413562

M. Rühling, L. Kersting, F. Wagner, F. Schumacher, D. Wigger, D.A. Helmerich, T. Pfeuffer, R. Elflein, C. Kappe, M. Sauer, C. Arenz, B. Kleuser, T. Rudel, M. Fraunholz*, Jürgen Seibel*
"Trifunctional sphingomyelin derivatives enable nanoscale resolution of sphingomyelin turnover in physiological and infection processes via expansion microscopy"
Nat Commun 2024, 15, early online.

P. Maurya, M. Kumar, R. Jain, H.T. Abdulhameed Almuqdadi, H. Singh, A. Gupta, C. Arenz, N.A. Gaur*, S. Singh*
"Expression of Plasmodium major facilitator superfamily protein in transporters–D Candida identifies a drug transporter"
Fut. Microbiology 2024, online

2023

N. Coant, J.D. Bickel, R. Rahaim, Y. Otsuka, Y.-M. Choi, R. Xu, M. Simoes, C. Cariello, C. Mao, E.M. Saied, C. Arenz, T.P. Spicer, T.D. Bannister, P.J. Tonge, M.V. Airola, L. Scampavia, Y.A. Hannun, R.C. Rizzo, J.D. Haley*
"Neutral ceramidase-active site inhibitor chemotypes and binding modes"
Bioorg Med Chem 2023, 139, 106747-106751.

A. Behl R. Shoaib, F. De Leon, G. Kumari, M. Saini, E. Madan, V. Kumar, H. Singh, J. Kumari, P. Maurya, S. Garg, P.C. Mishra, C. Arenz and S. Singh*
"Targeting an essential Plasmodium cold shock protein to block growth and transmission of malaria parasite "
iScience 2023, 26 106637.

L.S. Kalinichenko, C. Muhle, T. Jia, F. Anderheiden, M. Datz, A.L. Eberle, V. Eulenburg, J. Granzow, M. Hofer, J. Hohenschild, S.E. Huber, S. Kampf, G. Kogias, L. Lacatusu, C. Lugmair, S.M. Taku, D. Meixner, N.K. Sembritzki, M. Praetner, C. Rhein, C. Sauer, J. Scholz, F. Ulrich, F. Valenta, E. Weigand, M. Werner, N. Tay, C.J. Mc Veigh, J. Haase, A.L. Wang, L. Abdel-Hafiz, J.P. Huston, I. Smaga, M. Frankowska, M. Filip, A. Lourdusamy, P. Kirchner, A.B. Ekici, L.M. Marx, N.P. Suresh, R. Frischknecht, A. Fejtova, E.M. Saied, C. Arenz, A. Bozec, I. Wank, S. Kreitz, A. Hess, T. Bauerle, M.D. Ledesma, D.N. Mitroi, A.M. Miranda, T.G. Oliveira, B. Lenz, G. Schumann, J. Kornhuber, C.P. Muller*
"Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males"
Cereb Cortex 2023, 33 844–864.

2022

T. Jiang, R. Samapati, S. Klassen, D. Lei, L. Erfinanda, V. Jankowski, S. Simmons, J. Yin, C. Arenz, A. Dietrich, T. Gudermann, D. Adam, M. Schaefer, J. Jankowski, V. Flockerzi, R. Nusing, S. Uhlig, W.M. Kuebler*
"Stimulation of the EP3 receptor causes lung edema by activation of TRPC6 in pulmonary endothelial cells"
Eur Respir J 2022, 60 2102635.

Y. Feng, Z. Kochovski, C. Arenz, Y. Lu, J. Kneipp*
"Structure and Interaction of Ceramide-Containing Liposomes with Gold Nanoparticles as Characterized by SERS and Cryo-EM"
J. Phys. Chem. C 2022, 126 13237–13246.

Y.M. Suleimen, R.A. Jose, R.N. Suleimen, C. Arenz, M.Y. Ishmuratova, S. Toppet, W. Dehaen, B.A. Alsfouk, E.B. Elkaeed, I.H. Eissa, A.M. Metwaly*
"Jusanin, a New Flavonoid from Artemisia commutata with an In Silico Inhibitory Potential against the SARS-CoV-2 Main Protease"
Molecules 2022, 27 , DOI 10.3390/molecules27051636.

Y.M. Suleimen, R.A. Jose, R.N. Suleimen, C. Arenz, M. Ishmuratova, S. Toppet, W. Dehaen, A.A.Alsfouk, E.B. Elkaeed, I.H. Eissa, A.M. Metwaly*
"Isolation and In Silico Anti-SARS-CoV-2 Papain-Like Protease Potentialities of Two Rare 2-Phenoxychromone Derivatives from Artemisia spp"
Molecules 2022, 27 , DOI 10.3390/molecules27041216.

R.D. Healey,§ E.M. Saied,§ X. Cong, G. Karsai, L. Gabellier, J. Saint Paul, E. Del Nero, S. Jeannot, M. Drapeau, S. Fontanel, D. Maurel, S. Basu, C. Leyrat, J. Golebiowski, G. Bossis, C. Bechara, T. Hornemann, C. Arenz, S. Granier* § = equal contribution
"Discovery and mechanism of action of small molecule inhibitors of ceramidases"
Angew. Chem. Int. Ed. 2022, 61 , e202109967.

2021

T. Wang, Z. Wang, L. de Fabritus, J. Tao, E.M. Saied, H-J Lee, B.R. Ramazanov, B. Jackson, D. Burkhardt, M. Parker, A.S. Gleinich, Z. Wang, D.E. Seo, T. Zhou, S. Xu, Irina Alecu, P. Azadi, C. Arenz, T. Hornemann, S. Krishnaswamy, S.A. van de Pavert, S.M. Kaech, N.B. Ivanova, F.R. Santori*
"1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development"
Dev Cell 2021, accepted

L.S. Kalinichenko, C. Mühle, N. Tay, T. Jia, F. Anderheiden, M. Datz, A-L. Eberle, V. Eulenburg, J. Granzow, M. Hofer, J. Hohenschild, S. Huber, S. Kämpf, G. Kogias, L. Lacatusu, C. Lugmaier, S. Mbu Taku, D. Meixner, N. Tesch, M. Preatner, C. Rhein, C. Sauer, J. Scholz, F. Ulrich, F. Valenta, E. Weigand, M. Werner, C.J. Mc Veigh, J. Haase, A-L. Wang, L. Abdel-Hafiz, J.P. Huston, I. Smaga, M. Frankowska, M. Filip, A. Lourdusamy, P. Kirchner, A.B. Ekici, L. Marx, N.P. Suresh, R. Frischknecht, A. Fejtova, E.M. Saied, C. Arenz, A. Bozec, I. Wank, S. Kreitz, A. Hess, T. Bäuerle, M.D. Ledesma, A.M. Miranda, T.G. Oliveira, E. Gulbins, B. Lenz, G. Schumann, J. Kornhuber, C.P. Müller*
"Neutral sphingomyelinase mediates the comorbidity trias of alcohol abuse, major depression and bone defects"
Mol Psychiatry 2021, accepted, MS No 2021MP000962RR.

E. M. Saied and C.Arenz*
"Stereoselective Synthesis of Novel Sphingoid Bases Utilized for Exploring the Secrets of Sphinx"
Int J Mol Sci 2021, accepted.

Z.H. Mohamed, C. Rhein, B. Schmid, P. Tripal, J. Kornhuber and C. Arenz*
"Synthesis and Characterization of a New Two Photon Excitable Acid Sphingomyelinase FRET Probe"
<"> Bioorg Med Chem 2021, accepted, BMCHEM-D-21-00409R1.

G. Naseri*, K. Prause, H.H. Hamdo, C. Arenz
"Artificial transcription factors for tuneable gene expression in Pichia pastoris"
Front. Bioeng. Biotech. 2021, accepted, DOI:10.3389/fbioe.2021.676900

T.C.B. Santos, E.M. Saied, C. Arenz, A. Fedorov, M. Prieto, L.C. Silva*
"The long chain base unsaturation has a stronger impact on 1-deoxy(methyl)-sphingolipids biophysical properties than the structure of its C1 functional group"
BBA - Biomembranes 2021, accepted, BBAMEM-21-41R1.

M.J McVey,S. Weidenfeld, M. Maishan, C. Spring, M. Kim, A. Tabuchi, V. Srbely, A. Takabe-French, S. Simmons, C. Arenz, J.W. Semple, W. Kuebler*
"Platelet Extracellular Vesicles mediate Transfusion-related Acute Lung Injury by imbalancing the Sphingolipid Rheostat"
Blood 2021, accepted, DOI: 10.1182/Blood.2020005985

Y. Otsuka, M. V. Airola, Y. M. Choi, N. Coant, J. Snider, C. Cariello, E. M. Saied, C. Arenz, T. Bannister, R. Rahaim, Jr., Y. A. Hannun, J. Shumate, L. Scampavia, J. D. Haley, T. P. Spicer*
"Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening"
SLAS Discov. 2021, in press doi:10.1177/2472555220945283

2020

K. Prause, G. Naseri, F. Schumacher, C. Kappe, B. Kleuser and C. Arenz*
"A photocaged inhibitor of acid sphingomyelinase"
Chem. Commun. 2020, 56, 14885 - 14888.

D. Samaha, H.H. Hamdo, X. Cong, F. Schumacher, S. Banhart, Ö. Aglar, H. M. Möller, D. Heuer, B. Kleuser, E. M. Saied* and C. Arenz*
"A liposomal FRET assay identifies potent drug-like inhibitors of the ceramide transport protein CERT"
Chemistry - Eur J 2020, in press

M. Boss and C. Arenz*
"Analyse von zirkulären RNAs mithilfe der rolling circle amplification"
Biospektrum 2020, 6 635-638

Y. Otsuka, M. V. Airola, Y. M. Choi, N. Coant, J. Snider, C. Cariello, E. M. Saied, C. Arenz, T. Bannister, R. Rahaim, Jr., Y. A. Hannun, J. Shumate, L. Scampavia, J. D. Haley, T. P. Spicer*
"Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening"
SLAS Discov. 2020, in press doi:10.1177/2472555220945283

M. A. Lone , A. J. Huelsmeier , E.M. Saied , G. Karsai , C. Arenz , A. von Eckardstein , T. Hornemann*
"Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases"
Proc Natl Acad Sci USA 2020, in press doi: 10.1002/ange.202002459

T. C. B. Santos, A. Vaz, A. E. Ventura, E. M. Saied, C. Arenz, A. Fedorov, M. Prieto, L. C. Silva*
“Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties”
Langmuir 2020, in press DOI: 10.1021/acs.langmuir.0c01000

C. Kirschbaum, E.M. Saied, K. Greis, E. Mucha, S. Gewinner, W. Schöllkopf, G.J.M. Meijer, G. von Helden, B.L.J. Poad, S.J. Blanksby, C. Arenz* and K. Pagel*
“Resolving Sphingolipid Isomers using Cryogenic Infrared Spectroscopy”
Angew Chem 2020, in press doi: 10.1002/ange.202002459

N. Loibl, C. Arenz* and O. Seitz*
“Monitoring Dicer-mediated miRNA-21 maturation and Ago2 loading by a dual colour FIT PNA probe set”
ChemBioChem 2020, in press doi: 10.1002/cbic.202000173

E. M. Saied and C.Arenz*
"Synthesis and Characterization of Novel Atypical Sphingoid Bases"
ChemRxiv 2020, DOI:10.26434/chemrxiv.12094041.v1209404.

E. Naser, S. Kadow, F. Schumacher, Z. H. Mohamed, C. Kappe, G. Hessler, B. Pollmeier, B. Kleuser, C. Arenz, K. A. Becker, E. Gulbins, A. Carpinteiro*
“Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro.”
J Lipid Res 2020, in press doi: 10.1194/jlr.RA120000682

C. Kappe, Z. H. Mohamed, E. Naser, A. Carpinteiro, C. Arenz*
"A novel visible range FRET probe for monitoring acid sphingomyelinase activity in living cells"
Chemistry - European Journal 2020, accepted paper.

L. Laraia, G. Garivet, D. J. Foley, N. Kaiser, S. Müller, S. Zinken, T. Pinkert, J. Wilke, D. Corkery, A. Pahl, S. Sievers, P. Janning, C. Arenz, Y. Wu, R. Rodriguez, H. Waldmann*
"Image-based morphological profiling identifies a lysosomotropic, iron-sequestering autophagy inhibitor"
Angew. Chem. 2020, accepted: DOI:10.1002/anie.201913712.

M. Boss and C. Arenz*
"A Fast and Easy Method for Specific Detection of circRNA by Rolling Circle Amplification"
ChemBioChem 2020, 21793-796.

2019

D. Samaha, H.H. Hamdo, M. Wilde, K. Prause, C. Arenz*
"Sphingolipid transporting enzymes as cancer therapeutic targets (Review)"
Int J. Med Sci. (Molecular Oncology) 2019, 20, 3554.

V. Živanovic, Seifert, Drescher, P. Schrade, S. Werner, P. Guttmann, G. P. Szekeres, S. Bachmann, G. Schneider, C. Arenz, J. Kneipp*
"Optical Nanosensing of Lipid Accumulation due to Enzyme Inhibition in Live Cells"
ACS Nano. 2019, 13, 9363-9375.

2018

I. Vasiliauskaité-Brooks, R. D. Healey, P. Rochaix, R. Sounier, C. Grison, T. Waltrich-Augusto, M. Fortier, F. Hoh, E.M. Saied, C. Arenz, S. Basu, C. Leyrat*, S. Granier*
"Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy"
Nat.Commun. 2018, 9, 5437.

V. Živanovic, Z. Kochovski, C. Arenz, Y. Lu, and J. Kneipp*
"SERS and Cryo-EM Directly Reveal Different Liposome Structures During Interaction with Gold Nanoparticles"
J Phys Chem Lett 2018, 9,6767-6772.

Z. H. Mohamed, T. Soukka, C. Arenz, M. Schäferling*
"Five-, four- and three-dentate europium chelates for anion sensing and their applicability to enzymatic dephosphorylation reactions"
Chemistry Select 2018, 3,12430-12439.

Z. H. Mohamed, C. Rhein, E. M. Saied, J. Kornhuber, C. Arenz*
"FRET probes for measuring sphingolipid metabolizing enzyme activity (Review)"
Chem. Phys. Lipids 2018, 216,152-161.

J. Ren, E. M. Saied, A. Zhong, J. Snider, C. Ruiz, C. Arenz, L. M. Obeid, G. D. Girnun, Y. A. Hannun*
"Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in sphingolipid pathway"
J. Lipid Res. 2018, 59, 2126-2139.

E. M. Saied, T. L.-S. Le, T. Hornemann and C.Arenz*
"Synthesis and Characterization of some Atypical Sphingoid Bases"
Bioorg Med Chem 2018, 26, 4047-4057.

B. L. J. Poad*, A. T. Maccarone, H. Yu, T. W. Mitchell, E. M. Saied, C. Arenz, T. Hornemann, J. N. Bull, E. J. Bieske, S. J. Blanksby*
"Differential-mobility spectrometry of 1-deoxysphingosine isomers: new insights into the gas phase structures of ionized lipids"
Anal Chem 2018, 90, 5343–5351.

B.F. Straub et al. "Trendbericht Organische Chemie 2017"
Nachr Chem 2018, 65, 249-280.

2017

K. Hinrichs, T. Shaykhutdinov, C. Kratz, F. Rösicke, C. Schöniger, C. Arenz, N.H. Nickel, J. Rappich
"Electrochemical Modification of Large Area Graphene and Characterization by Vibrational Spectroscopy"
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering (Elsevier) 2017, DOI 10.1016/B978-0-12-409547-2.14194-0

V. Zivanovic, F. Madzharova, Z. Heiner, C. Arenz, J. Kneipp*
"Specific Interaction of Tricyclic Antidepressants With Gold and Silver Nanostructures as Revealed by Combined One and Two-Photon Vibrational Spectroscopy"
J. Phys. Chem. C 2017, 121 22958-22968.

I. Vasiliauskaité-Brooks, R. Sounier, P. Rochaix, G. Bellot, M. Fortier, F. Hoh, L. De Colibus, C. Bechara, E.M. Saied, C. Arenz, C. Leyrat*, S. Granier*
"Structural insights into adiponectin receptors suggest ceramidase activity"
Nature 2017, 544, 120-123.

L. Collenburg, N. Beyersdorf, C. Arenz, E. M. Saied, E. Avota, S. Schneider-Schaulies*
"The activity of the neutral sphingomyelinase is important in T cell recruitment and directional migration"
Front. Immunol. 2017, 8, 1007.

C. Arenz* "Recent advances and novel treatments for sphingolipidoses (Review)"
Future Med Chem 2017, 9, 1687-1700.

S. Koch-Edelmann, S. Banhart, E. M. Saied, L. Rose, L. Aeberhard, M. Laue, J. Doellinger, C. Arenz and D. Heuer*
"The cellular ceramide transport protein CERT promotes Chlamydia psittaci infection and controls bacterial sphingolipid uptake"
Cell Microbiol 2017, 19, e12752, doi: 110.1111/cmi.12752.

M. McVey, M. Kim, A. Tabuchi, V. Srbely, L. Japtok, C. Arenz, O. Rotstein, B. Kleuser, J. Semple, W. Kuebler*
"Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets"
Am J Physiol Lung Cell Mol Physiol. 2017, 312, L625-L637

T. Pinkert, D. Furkert, T. Korte, A. Herrmann, C. Arenz*
"Lipid-Water Partition-Amplified FRET Probe for Life-Cell Detection of Acid Sphingomyelinase"
Angew. Chem. 2017, 129, 2834–2838.

B.F. Straub et al. "Trendbericht Organische Chemie 2016"
Nachr Chem 2017, 64, 266-304.

M. Sharar, E.M. Saied, M. Corte, C. Arenz, M. Linscheid, M. Montes-Bayón*
"Elemental Labelling and Mass Spectrometry for the Specific Detecion of Sulfenic Acid Groups in Model Peptides: A Proof of Concept"
Anal. Bioanal. Chem. 2017, 409, 2015-2027.

I. Alecu, A. Othman, A. Penno, E.M. Saied, C. Arenz, A. von Eckardstein and T. Hornemann*
"Cytotoxic 1-Deoxysphingolipids Are Metabolized by a Cytochrome P450-Dependent Pathway"
J. Lipid Res. 2017, 58, 60-71.

2016

J. Sosna, S. Philipp, J. Fuchslocher Chico, C. Saggau, J. Fritsch, A. Föll, J. Plenge, C. Arenz, T. Pinkert, H. Kalthoff, A. Trauzold, I. Schmitz, S. Schütze, D. Adam "Differences and similarities in TRAIL- and TNF-mediated necroptotic signaling in cancer cells"
Mol. Cell Biol. 2016, 36 2626-44.

R. Steiner*, E.M. Saied*, A. Othman, C. Arenz, A.T. Maccarone, B.L.J. Poad, S.J. Blanksby, A. von Eckardstein, T. Horneman "Elucidating the chemical structure of native 1-deoxysphingosine"
J. Lipid Res. 2016, 57, 1194-1203.

T. Kirkegaard, J. Gray, D.A. Priestman, K.-L. Wallom, J. Atkins, O.D. Olsen, A. Klein, S. Drndarski, L. Ingemann, C. Bornæs, S.H. Jørgensen, I. Williams, A. Hinsby, C. Arenz, D. Begley, M. Jäättelä, F.M. Platt "Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses"
Science Transl Med 2016, 8, 355RA118.

B.F. Straub et al. "Trendbericht Organische Chemie 2015"
Nachr Chem 2016, 63, 255-294.

M. Hesse and C. Arenz* "A rapid and versatile assay of Ago2-mediated cleavage using branched rolling circle amplification"
ChemBioChem 2016, 17, 304-307.

E. M. Saied, C. Arenz* "Inhibitors of Ceramidases"
Chem Phys Lipids 2016, 19760-68.

2015

E. M. Saied, S. Banhart, S. E. Bürkle, D. Heuer, C. Arenz* "A Series of Ceramide Analogues Modified at the 1-Position With Potent Activity Against the Intracellular Growth of Chlamydia trachomatis"
Future Med Chem 2015, 7, 1971-1980.

C. Tabeling, H. Yu, L. Wang, H. Ranke, N. M. Goldenberg, D. Zabini, E. Noe, A. Krauszman, B. Gutbier, J. Yin, M. Schaefer, C. Arenz, A. C. Hocke, N. Suttorp, R. L. Proia, M. Witzenrath, W. M. Kuebler* "CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction"
Proc Natl Acad Sci USA 2015, 112, E1614–E1623.

B.F. Straub et al. "Trendbericht Organische Chemie 2014"
Nachr Chem 2014, 62, 264-301.

N. Ogorodnikova and C. Arenz* "miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650"
Expert Opin Ther Pat. 2015, 25, 723-727

2014

M. Hesse and C. Arenz* "miRNAs as novel therapeutic targets and diagnostic biomarkers for Parkinson's disease: a patent evaluation of WO2014018650"
Expert Opin Ther Pat. 2014, 11, 1271-6

S. Banhart, E. M. Saied, A. Martini, S. Koch, L. Aeberhard, K. Madela, C. Arenz, and D. Heuer* "Improved plaque assay identifies a novel anti-Chlamydia ceramide derivative with altered intracellular localization"
Antimicrob. Agents Chemother. 2014, 58, 5537-5546

E. M. Saied, C. Arenz* "Small Molecule Inhibitors of Ceramidases"
Cell Phys Biochem 2014, 34, 197-212.

E. M. Saied, S. Diederich, C. Arenz* "Facile Synthesis of the CERT Inhibitor HPA-12 and Some Novel Derivatives"
Chem Asian J 2014, 9 2092–2094.

S. Voigt, S. Philipp, P. Davarnia, S. Winoto-Morbach, C. Röder, C. Arenz, A. Trauzold, D. Kabelitz, S. Schütze, H. Kalthoff and D. Adam* "TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells"
BMC Cancer 2014, 14, 74.

G. Schwarzmann*, C. Arenz*, K. Sandhoff* "Labeled Chemical Biology Tools for Investigating Sphingolipid Metabolism, Trafficking and Interaction with Lipids and Proteins"
BBA - Molecular and Cell Biology of Lipids 2014, in press

S. Bräse et al. "Trendbericht Organische Chemie 2013"
Nachr Chem 2014, 62, 264-301.

M. Hesse, C. Arenz* "Micro RNA maturation and human disease (Review)"
Meth Mol Biol (Ed. C. Arenz) 2014, 1095, 11-25.

M. Hesse, B.P. Davies, C. Arenz* "Assaying Dicer-mediated miRNA maturation by means of fluorescent substrates"
Meth Mol Biol (Ed. C. Arenz) 2014, 1095, 95-102.

S. Neubacher, C. Arenz* "Assaying micro RNA Maturation Using Unmodified pre-miRNA"
Meth Mol Biol (Ed. C. Arenz) 2014, 1095, 109-119.

2013

N. H. T. Petersen, O. D. Olsen, L. Groth-Pedersen, A. M. Ellegaard, M. Bilgin, S. Redmer, M. S. Ostenfeld, D. Ulanet, T. H. Dovmark, A. Lønborg, S. D. Vindeløv, D. Hanahan, C. Arenz, C. S. Ejsing, T. Kirkegaard, M. Rhode, J. Nylandsted, M. Jäättelä* "Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase"
Cancer Cell 2013, 24, 379-393.

A. A. Bastian, E. M. Warszawik, P. Panduru, C. Arenz and A. Herrmann* "Regioselective Diazo-Transfer Reaction at the C3-Position of the 2-Desoxystreptamine Ring of Neamine Antibiotics"
Chem Eur J 2013, 19, 9151–9154.

K. P. Bhabak, A. Hauser, S. Redmer, S. Banhart, D. Heuer, C. Arenz* "Development of a Novel FRET Probe for the Real-Time Determination of Ceramidase Activities"
ChemBioChem 2013, 14, 1049-1052.

C. Schöniger, C. Arenz* "Perspectives in targeting miRNA function"
Bioorg. Med. Chem. 2013, 21,6115-6118

C. M. Dojahn, M. Hesse, C. Arenz* "Chemo-enzymatic Approach to specifically click-modified RNA"
Chem. Commun. 2013, 49, 3128-3130

S. Bräse et al. "Trendbericht Organische Chemie 2012"
Nachr Chem 2013, 61, 265-297.

K. P. Bhabak, C. Arenz* "Novel Drugs Targeting Sphingolipid Metabolism" (Book Chapter)
Handb Exp Pharmacol. (Editors: E. Gulbins, I Petrache) 2013, 215, 187-196.

K. P. Bhabak, B. Kleuser, A. Huwiler, C. Arenz* "Effective Inhibition of Acid and Neutral Ceramidases by Novel B-13 and LCL-464 analogues"
Bioorg. Med. Chem. 2013, 21, 874-882.

2012

K. P. Bhabak, C. Arenz* "Novel Amide- and Sulfonamide-based Aromatic Ethanolamines: Effects of Various Substituents on the Inhibition of Acid and Neutral Ceramidases"
Bioorg. Med. Chem. 2012, 20, 6162-6170

K. P. Bhabak, D. Proksch, S. Redmer, C. Arenz* "Novel Fluorescent Ceramide Derivatives for Probing Ceramidase Substrate Specificity"
Bioorg. Med. Chem. 2012, 20, 6154-6161

S. Bräse et al. "Trendbericht Organische Chemie 2011"
Nachr Chem 2012, 60, 265-299.

R. Samapati, Y. Yang, J. Yin, C. Arenz, A. Dietrich, T. Gudermann, D. Adam, S. Wu, C. Stoerger, V. Flockerzi, S. Uhlig*, W.M. Kübler* "Regulation of lung vascular permeability by acid sphingomyelinase dependent activation of TRPC6"
Am J Respir Crit Care Med. 2012, 185, 160-170

M. Sand*, M. Skrygan, C. Arenz, D. Georgas, T. Gambichler, D. Sand, P. Altmeyer, F.G. Bechara "Expression Levels of the microRNA Maturing Microprocessor Complex Component DGCR8 and the RNA-Induced Silencing Complex (RISC) Components Argonaute-1, Argonaute-2, PACT, TARBP1, and TARBP2 in Epithelial Skin Cancer"
Mol. Carcinog. 2011, 51, 916-922

2011

S. Neubacher, C.M. Dojahn, C. Arenz "A Rapid Assay for miRNA Maturation using Unmodified pre-miRNA"
ChemBioChem. 2011, 12, 2302-2305

S. Bräse et al. "Trendbericht Organische Chemie 2010"
Nachr Chem 2011, 59, 254-283.

D. Proksch, J.J. Klein, C. Arenz "Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues"J. Lipids 2011, doi:10.1155/2011/971618 PDF

2010

S. Wetzel, W. Wilk, S. Chamma, B. Sperl, A.G. Roth, A. Yektaoglu, S. Renner, T. Berg, C. Arenz, A. Giannis, T.I. Oprea, D. Rauh, M. Kaiser, and H. Waldmann, "A Scaffold Tree Merging Strategy for Prospective Bioactivity Annotation of gamma-pyrones"
Angew. Chem. Int. Ed. 2010, 49, 3666-3670

S. Bräse et al. "Trendbericht Organische Chemie 2009"
Nachr Chem 2010, 58, 267-299

C. Arenz "Small Molecule Inhibitors of Acid Sphingomyelinase"
Cell Phys Biochem 2010, 26, 1-8

T. Kirkegaard, A. G. Roth, N. H. T. Petersen, A. K. Mahalka, O. D. Olsen, I. Moilanen, A. Zylicz, J. Knudsen, K. Sandhoff, C. Arenz, P. K. J. Kinnunen, J. Nylandsted, M. Jäättelä "Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology"
Nature 2010, 463, 549-554

A. G. Roth, S. Redmer and C. Arenz "Carbohydrate-Derived Inhibitors of Acid Sphingomyelinase"
Bioorg. Med. Chem. 2010, 18, 939-944.

2009

A. G. Roth, D. Drescher, Y. Yang, S. Redmer, S. Uhlig, C. Arenz "Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates"
Angew. Chem. Int. Ed. 2009, 48, 7560-7563.

Anke G. Roth, S. Redmer, C. Arenz "Potent Inhibition of Acid Sphingomyelinase by Phosphoinositide Analogues"
ChemBioChem. 2009, 2367-2374.

S. Neubacher, C. Arenz "Rolling Circle Amplification: Unshared Advantages in miRNA Detection"
ChemBioChem. 2009, 10 (8), 1289-1291.

C. M. Klemm, A. Berthelmann, S. Neubacher, C. Arenz
"Short and Efficient Synthesis of Alkyne-Modified Aminoglycoside Building Blocks"
Eur. J. Org. Chem. 2009, 17, 2788-2794.

2008

B. P. Davies, C. Arenz "A Fluorescence Probe for Assaying micro RNA maturation" Bioorg. Med. Chem. 2008, 16, 49-55.

2007

J. O. Babalola, M. Wendeler, B. Breiden, C. Arenz, G. Schwarzmann, S. Locatelli-Hoops, K. Sandhoff
"Development of an Assay for the Intermembrane Transfer of Cholesterol by Niemann-Pick C2 Protein" Biol. Chem.2007, 388, 617-626.

C. Arenz, O. Seitz "DNA Made of Purines Only" (Preview) Chem. Biol. 2007, 14, 467-469.

2006

C. Arenz, "Peptidnukleinsäuren in der Biomedizin"
Nachr. Chem. 2006, 54, 270-273.

B. P. Davies, C. Arenz "A Homogenous Assay for Micro RNA Maturation" Angew. Chem. Int. Ed. Engl. 2006, 45, 5550-5552.

C. Arenz "MicroRNAs - Future Drug Targets?" (Highlight) Angew. Chem. Int. Ed. Engl. 2006, 45, 5048-5050.

 

earlier publications

Publication list (PDF-file)

ResearcherID (external link)