Working hypothesis
(Read more at Humboldt University)
Prof. Dr. Bernhard Grimm | Humboldt University
- Multi-enzymatic protein complex senses the steady state levels of Mg-porphyrins resulting in a feedback-regulated control of ALA synthesis and metabolic flow.
- Tetrapyrrole biosynthesis is a measure/sensor of early plastid development and biogenesis
» Changes in the Mg branch induces changes in transcripional activities for plastid localized proteins
Consequences of tetrapyrrole-derived signaling
Reduced activities in the Mg branch reduce transcript levels
Enhanced activities in the Mg branch increase transcript levels
Research objectives
- Global transcriptome analysis induced by tetrapyrrole-mediated signaling
- Strategies to identify new regulatory or signaling proteins of the protein complex in the Mg branch