Summary
The term retrograde signaling in plant sciences refers to the regulation of the expression of nuclear genes in response to changes in the metabolic and developmental state of plastids (and mitochondria). Genetic, physiological and transcriptomic studies suggest the existence of several retrograde signaling pathways by which plastids (as well as mitochondria) elicit specific physiological and developmental responses and modifies the expression strength of nuclear genes. Whereas it is widely accepted that these pathways contribute to a complex signaling network that links the functional and physiological state of the plastid and of other compartments to the activities in the nucleus,
- only a small number of signaling components have been tentatively identified so far,
- knowledge of the response of the nuclear transcriptome to retrograde signals is incomplete,
- regulatory cis and trans-factors remain largely unknown.
The unifying goal of the Research Unit is to dissect the intracellular regulatory network(s) from plastids to nucleus to which retrograde signals contribute and to unravel the elements and interdependencies of separate signaling pathways. This will be achieved by the identification and validation
- of signal components of the different signal transduction pathways between plastids and the nucleus
- of target genes of plastid-to-nucleus signals and their promoters,
- of interactions between the different signaling pathways
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