Role of cell adhesion receptors of the CEA family in leucocyte function

Role of cell adhesion receptors of the CEA family in leucocyte function
	The main focus of this project will be the analyses of the biological function and the molecular mechanism triggered by proteins of the CEA-family (CEACAMs/CD66) in different leukocyte subpopulations. CEACAMs are cell adhesion receptors which recently were shown to modulate various lymphocyte functions. We will thoroughly characterize the CEACAM-expression profile using different well-established cell lines of lymphocyte and promyelocyte origin as well as primary lymphocytes and granulocytes. Additionally we will use various CEACAM specific ligands (antibodies, Fc-constructs) to induce signaling pathways and functions in resting and stimulated leukocyte subpopulations. As a result, we expect to gain new insights into the physiological role of CEACAMs in modulating the innate and adaptive immunity.
Head of Project:
	Dr. rer. nat. Bernhard Singer Charité - Universitätsmedizin Berlin Institute of Biochemistry and Molecular Biology CBF
Begin/End of Project:
	01/2005- 12/2005
Funded by:
	Universitäre Forschungsförderung Charité