Vitamin D3, Selen und Krebs


The aim of the proposed project is to assess the association between vitamin D3 and selenium deficiency and cancer incidence and mortality for all cancers as well as for specific cancer sites (including colorectal, lung, breast and prostate cancer) in the ESTHER study in Germany. The ESTHER study, a large scale population-based cohort study (ESTHER = Epidemiologische Studie zu Chancen der Verhütung, Früherkennung und optimierten Therapie chronischer Erkrankungen in der älteren Bevölkerung ), aimed to evaluate new approaches to the prevention, early detection and therapy of chronic diseases among older adults, is conducted in Saarland, a state located in South-West Germany (Principle investigator: H. Brenner, DKFZ Heidelberg). 1. Measurement of Vitamin D3 levels in serum samples collected at baseline (only for male participants; for female participants Vitamin D3 levels have already been measured within another project). 2. Measurement of selenium status using selenoprotein P as parameter in serum samples collected at baseline Measurements: Institut für Experimentelle Endokrinologie, Charité Universitätsmedizin Berlin. 3. Linkage of the ESTHER cohort to the Saarland cancer registry data to allow 7 year follow-up (starting in 2008) and 10 year follow-up (starting in 2010) regarding cancer incidence and mortality.
Head of Project:

Univ.Prof.Dr. Josef Köhrle
Charité - Universitätsmedizin Berlin
Institute of Experimental Endocrinology CCM
Tel. 450-524-021
Fax 450-524-922
josef.koehrle@charite.de
Additional Head of Project:

Prof. Dr. Lutz Schomburg
Begin/End of Project:

10/2008 - 12/2011
Funded by:

Deutsche Krebshilfe e.V.