ICSB is the leading and largest systems biology conference in the world, with an uninterrupted row of annual conferences held around the world from 2000 to 2019. The overarching theme for 2022 is “Global life science challenges in the post-pandemic world” and will focus on multiscale biomes from microbiomes, tumors, host & pathogens to ecosystems. ICSB2022 will be the first ICSB conference since the pandemic. We strongly believe that the community needs to have a large in-person international get-together to kick-start systems biology research and collaboration in the post-pandemic world. Thus, our meeting aims to engage with the global community and ensure ample opportunities for collaboration and in-depth discussions to take place throughout the conference. The ICSB is the official conference of the International Society on Systems Biology, each year featuring a series of talks by world-leading thought- and decision-makers in the fields of cell signaling, complex systems, network- and genome biology, functional genomics and disease systems biology.