We are studying molecular function of transcriptional co-regulatory machineries in plants. Our current focus it to understand how plant co-regulators act together with transcription factors in the plant cell to regulate the expression of the downstream genes. Majority of Eukaryotic transcription factors do not act on their own, they form multimeric protein complexes with co-repressors or co-activators that modulate the function of the transcription factors. In general, we know surprisingly little about the specificity of these co-regulatory proteins, their composition and effector actions. What are the molecular machineries that assemble on repressed vs. activated genes, and what is the underlying grammar of their specific interaction? This is, among others, our main research question that we are trying to address. We are using a multidisciplinary approach, combining proteomics and genomics with mathematical modelling and deep learning to study the cofactor function in plants.
If you are interested in joining our group as a PhD student or a postdoc, please contact Cezary Smaczniak by sending your CV and a motivation e-mail. At the moment, we do not have open positions but there are possibilities of applying for fellowships through e.g. Alexander von Humboldt Foundation, EMBO, EU Marie Skłodowska-Curie Actions, etc.
If you are interested in joining our group as a master or bachelor student, please contact Cezary Smaczniak by sending your transcript of records and a motivation e-mail. We usually have topics for master and bachelor thesis projects.