Welcome to the AG Bacterial Physiology!

Research summary

Life has evolved diverse protein machines and bacteria provide many fascinating examples.

Flagella are the primary organelles of motility in bacteria and enable movement towards nutrients and away from harmful substances, a process known as chemotaxis. Flagella-mediated motility is also important for many pathogens – including Salmonella enterica – and allows the bacteria to reach the site of infection, facilitate host-pathogen interactions, and promote biofilm formation.

The bacterial flagellum is by far the most prominent extracellular structure known in bacteria and made through self-assembly of several tens of thousand individual building blocks. However, many questions concerning the regulation, organization and assembly of this remarkably complex motility organelle remain poorly understood.

We use a combination of genetic engineering, biochemistry and fluorescent microscopy techniques to understand the genetic regulation, self-assembly and protein export mechanisms of this fascinating nanomachine.

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Recent lab news

September 6, 2018

Imke's paper on how the hook length of the bacterial flagellum is optimized for maximal maximal motility performance has been published in PLoS Biology! Congrats Imke!

May 1, 2018

A new paper how flagella synthesis is regulated in response to cell envelope stress has been published in mBio! Congrats Imke and Basti!

November 28, 2017

In collaboration with Kelly T. Hughes and David F. Blair at the University of Utah, we show that the secretion pore of the flagellar type-III protein export apparatus is formed by the protein FliP. Published in Molecular Microbiology!

August 3, 2017

Florian's paper on the role of FliO as a flagellum-specific chaperone has been published in PLoS Biology! Congrats!

June 14, 2017

The microbiota composition determines the susceptibility towards Salmonella-induced gastroenteritis. A collaborative work together with Till Strowig at the Helmholtz Centre for Infection Research. Published in Cell Host & Microbe!

April 18, 2017

Thibaud's paper on the mechanism of filament growth has been published in eLife! Congrats Thibaud!

AG Bacterial Physiology, July 2018